Епидемиология на придобитата тромботична тромбоцитопенична пурпура

  • Костадин Костадинов
  • Георги Стефанов
  • Георги Искров
  • Румен Стефанов
Keywords: придобита тромботична тромбоцитопенична пурпура, епидемиология, болестност

Abstract

Придобитата тромботична тромбоцитопенична пурпура (пТТП) представлява рядко заболяване с разнообразна клинична манифестация, включваща фебрилитет, анемия, тромбоцитопения, неврологична симптоматика и остро бъбречно увреждане. Познато и описано първоначално през 1924 г., днес са известни патофизиоимунологичните аспекти, отличаващи го от другите тромботични васкулопатии и служещи за таргет на иновативни терапии. ТТП се разделя на наследствена и придобита форма. Придобитата може да бъде идиопатична или вторична. Актуалната класификация на Световната здравна организация дефинира ТТП към категорията на тромботичните микроангиопатии.

Изучаването на епидемиологията на пТТП представлява труден процес поради редица обективни фактори. Заболяването се характеризира със специфичен лабораторен имунологичен панел, който често е материално-технически необезпечено изследване за редица клинични центрове. Наличието на тежки клинични презентации, често срещани коморбидности и бърза летална прогресия са също пречка за установяване на реалната болестност.

Настоящата публикация има за цел да анализира епидемиологични данни за пТПП и да представи оценка за разпространението на това заболяване в България.

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Published
2020-10-16
How to Cite
1.
Костадинов К, Стефанов Г, Искров Г, Стефанов Р. Епидемиология на придобитата тромботична тромбоцитопенична пурпура. Редки болести и лекарства сираци [Internet]. 2020Oct.16 [cited 2024Dec.3];11(3):36-4. Available from: http://journal.raredis.org/index.php/RBLS/article/view/122
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